![]() ![]() In contrast, tuberculoid leprosy patients had only minor signal transduction alterations. An electrophoretic mobility shift assay with the gamma interferon core promoter region revealed a loss of the Th1 DNA-binding pattern in LL patients. Of 29 LL patients, 69% had decreased T-cell receptor ζ-chain expression, 48% had decreased p56 lck tyrosine kinase, and 63% had a loss of nuclear transcription factor NF-κB p65. These alterations were most frequently observed in lepromatous leprosy (LL) patients. The present report demonstrates major alterations in the expression of signal transduction molecules in T cells of leprosy patients. ![]() ![]() The basis of this T-cell dysfunction is not well understood. Advanced stages of mycobacterial diseases such as leprosy and tuberculosis are characterized by a loss of T-cell function. ![]()
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